Plasma γ-glutamyltransferase, cysteinyl-glycine, and oxidized low-density lipoprotein: a pathway associated with myocardial infarction risk?

Drogan, D.; Weikert, C.; Dierkes, J.; Klipstein-Grobusch, K.; Buijsse, B.; Moehlig, M.; Pfeiffer, A.F.; Pischon, T.; Spranger, J.; Boeing, H.

Plasma γ-glutamyltransferase, cysteinyl-glycine, and oxidized low-density lipoprotein: a pathway associated with myocardial infarction risk?

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Item Type:	Article
Title:	Plasma γ-glutamyltransferase, cysteinyl-glycine, and oxidized low-density lipoprotein: a pathway associated with myocardial infarction risk?
Creators Name:	Drogan, D., Weikert, C., Dierkes, J., Klipstein-Grobusch, K., Buijsse, B., Moehlig, M., Pfeiffer, A.F., Pischon, T., Spranger, J. and Boeing, H.
Abstract:	Objective-To investigate the interrelation between plasma {gamma}-glutamyltransferase (GGT) activity, cysteinyl-glycine (Cys-Gly) (ie, a thiol originating from GGT-mediated cleavage of glutathione), and oxidized low-density lipoprotein (oxLDL) with regard to myocardial infarction (MI) risk in a prospective study. Methods and Results-Incident cases of MI were identified among European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam participants without prior MI during 6.0 years of follow-up. Baseline levels of Cys-Gly and oxLDL and GGT activity in plasma were measured in a case-cohort study comprising 837 subjects without incident MI and 116 subjects with incident MI. The relation of GGT, Cys-Gly and oxLDL to MI risk was assessed using Cox proportional hazards regression analysis. After adjustment for established risk factors, hazard ratios associated with a 1-SD unit increase in the log-transformed biomarker were 1.63 (95% CI, 1.30 to 2.05) for GGT, 1.36 (95% CI, 1.07 to 1.72) for Cys-Gly, and 1.37 (95% CI, 1.00 to 1.86) for oxLDL. Cys-Gly and oxLDL accounted for 2.3% of the relation between GGT and MI risk. Conclusion-The positive association between GGT activity and MI risk appears to be independent of circulating Cys-Gly and oxLDL levels. With Cys-Gly, we found a potential new predictor of MI risk whose impact needs to be further elucidated.
Keywords:	{gamma}-Glutamyltransferase, Cysteinyl-Glycine, Oxidized LDL, Myocardial Infarction, Prospective Study
Source:	Arteriosclerosis Thrombosis and Vascular Biology
ISSN:	1079-5642
Publisher:	American Heart Association
Volume:	30
Number:	10
Page Range:	2053-2058
Date:	October 2010
Official Publication:	https://doi.org/10.1161/ATVBAHA.110.209346
PubMed:	View item in PubMed

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