Amplification of EDHF-type vasodilatations in TRPC1-deficient mice

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Item Type:	Article
Title:	Amplification of EDHF-type vasodilatations in TRPC1-deficient mice
Creators Name:	Schmidt, K., Dubrovska, G., Nielsen, G., Fesues, G., Uhrenholt, T.R., Hansen, P.B., Gudermann, T., Dietrich, A., Gollasch, M., de Wit, C. and Koehler, R.
Abstract:	TRPC1 channels are expressed in the vasculature and are putative candidates for intracellular Ca(2+) handling. However, little is known about their role in endothelium-dependent vasodilatations including endothelium-derived hyperpolarizing factor (EDHF) vasodilatations, which require activation of Ca(2+) -activated K(+) channels (K(Ca)). To provide molecular information on the role of TRPC1 for K(Ca) function and the EDHF signalling complex, we examined endothelium-dependent and independent vasodilatations, K(Ca) currents and smooth muscle contractility in TRPC1-deficient mice (TRPC1-/-).
Keywords:	Transient Receptor Potential Channels, BKCa, KCa3.1, KCa2.3, Endothelium-Derived Hyperpolarizing Factor, Endothelium, Arterial Smooth Muscle, Animals, Mice
Source:	British Journal of Pharmacology
ISSN:	0007-1188
Publisher:	Wiley
Volume:	161
Number:	8
Page Range:	1722-1733
Date:	December 2010
Official Publication:	https://doi.org/10.1111/j.1476-5381.2010.00985.x
PubMed:	View item in PubMed

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