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| Item Type: | Review |
|---|---|
| Title: | Nrg1/ErbB signaling networks in Schwann cell development and myelination |
| Creators Name: | Newbern, J. and Birchmeier, C. |
| Abstract: | Neuregulin-1 (Nrg1) provides a key axonal signal that regulates Schwann cell proliferation, migration and myelination through binding to ErbB2/3 receptors. The analysis of a number of genetic models has unmasked fundamental mechanisms underlying the specificity of the Nrg1/ErbB signaling axis. Differential expression of Nrg1 isoforms, Nrg1 processing, and ErbB receptor localization and trafficking represent important regulatory themes in the control of Nrg1/ErbB function. Nrg1 binding to ErbB2/3 receptors results in the activation of intracellular signal transduction pathways that initiate changes in Schwann cell behavior. Here, we review data that has defined the role of key Nrg1/ErbB signaling components like Shp2, ERK1/2, FAK, Rac1/Cdc42 and calcineurin in development of the Schwann cell lineage in vivo. Many of these regulators receive converging signals from other cues that are provided by Notch, integrin or G-protein coupled receptors. Signaling by multiple extracellular factors may act as key modifiers and allow Schwann cells at different developmental stages to respond in distinct manners to the Nrg1/ErbB signal. |
| Keywords: | Neuregulin, Shp2, Erk, Erbin, Myelination, Animals |
| Source: | Seminars in Cell & Developmental Biology |
| ISSN: | 1084-9521 |
| Publisher: | Academic Press |
| Volume: | 21 |
| Number: | 9 |
| Page Range: | 922-988 |
| Date: | December 2010 |
| Official Publication: | https://doi.org/10.1016/j.semcdb.2010.08.008 |
| PubMed: | View item in PubMed |
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