Do CARs need a driver's license? Adoptive cell therapy with chimeric antigen receptor-redirected T cells caused serious adverse events

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Item Type:	Editorial
Title:	Do CARs need a driver's license? Adoptive cell therapy with chimeric antigen receptor-redirected T cells caused serious adverse events
Creators Name:	Buening, H., Uckert, W., Cichutek, K., Hawkins, R.E. and Abken, H.
Abstract:	Adoptive transfer of genetically retargeted T cells provides promise in the therapy of malignant diseases; two severe adverse events, however, due to "on-targeted" activation of modified T cells occurred in recent trials. We here discuss the challenge to balance targeted anti-tumor responses whilst avoiding destruction of healthy tissues and the need of continued and carefully designed pre-clinical and clinical evaluations.
Keywords:	Adoptive Immunotherapy, Antigen Receptors, Clinical Trials, Lymphocyte Activation, Recombinant Proteins, T-Lymphocytes, Animals, Mice
Source:	Human Gene Therapy
ISSN:	1043-0342
Publisher:	Mary Ann Liebert
Volume:	21
Number:	9
Page Range:	1039-1042
Date:	September 2010
Official Publication:	https://doi.org/10.1089/hum.2010.131
PubMed:	View item in PubMed

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