Frequency of elemental events of intracellular Ca(2+) dynamics

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Item Type:	Article
Title:	Frequency of elemental events of intracellular Ca(2+) dynamics
Creators Name:	Thul, R. and Falcke, M.
Abstract:	The dynamics of intracellular Ca(2+) is driven by random events called Ca(2+) puffs, in which Ca(2+) is liberated from intracellular stores. We show that the emergence of Ca(2+) puffs can be mapped to an escape process. The mean first passage times that correspond to the stochastic fraction of puff periods are computed from a novel master equation and two Fokker-Planck equations. Our results demonstrate that the mathematical modeling of Ca(2+) puffs has to account for the discrete character of the Ca(2+) release sites and does not permit a continuous description of the number of open channels.
Keywords:	Calcium, Calcium Signaling, Intracellular Space, Biological Models
Source:	Physical Review E
ISSN:	1539-3755
Publisher:	American Physical Society
Volume:	73
Number:	6 Pt 1
Page Range:	061923
Date:	June 2006
Official Publication:	https://doi.org/10.1103/PhysRevE.73.061923
PubMed:	View item in PubMed

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