Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes

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Item Type:	Article
Title:	Primary structure of Torpedo marmorata chloride channel isolated by expression cloning in Xenopus oocytes
Creators Name:	Jentsch, T.J., Steinmeyer, K. and Schwarz, G.
Abstract:	A complementary DNA encoding a voltage-gated chloride channel from Torpedo marmorata electric organ was cloned by expressing hybrid-depleted messenger RNA in Xenopus oocytes. The predicted protein has a sequence of 805 amino acids containing several putative membrane-spanning domains. Expression of the protein in Xenopus oocytes shows that it is sufficient for channel function.
Keywords:	Amino Acid Sequence, Base Sequence, Cell Membrane, Chloride Channels, Chlorides, Molecular Cloning, DNA, Electric Conductivity, Gene Expression, Membrane Proteins, Molecular Sequence Data, Oocytes, Messenger RNA, Solubility, Animals, Xenopus Laevis
Source:	Nature
ISSN:	0028-0836
Publisher:	Nature Publishing Group
Volume:	348
Number:	6301
Page Range:	510-514
Date:	6 December 1990
Official Publication:	https://doi.org/10.1038/348510a0
PubMed:	View item in PubMed

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