Introduction to focus issue: intracellular Ca2+ dynamics--a change of modeling paradigm?

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Item Type:	Article
Title:	Introduction to focus issue: intracellular Ca2+ dynamics--a change of modeling paradigm?
Creators Name:	Falcke, M.
Abstract:	Intracellular Ca(2+) concentration dynamics have been perceived as a prototypical deterministic intracellular reaction-diffusion system in biophysics for many years. Recent experimental findings challenge that view and suggest them to be fluctuation driven. That renders this system interesting for nonlinear physics, in general, since we can study the emergence of macroscopic behavior from mesoscopic dynamics. In particular, we can observe the random elemental events, called puffs, and the macroscopic pattern with the same experimental means. Here, we give a short introduction to the current discussion on theoretical and modeling concepts, and this Focus Issue reflecting it.
Keywords:	Algorithms, Biological Clocks, Calcium Signaling, Computer Simulation, Biological Models, Statistical Models, Nonlinear Dynamics, Oscillometry, Animals
Source:	Chaos
ISSN:	1054-1500
Publisher:	American Institute of Physics
Volume:	19
Number:	3
Page Range:	037101
Date:	September 2009
Official Publication:	https://doi.org/10.1063/1.3234259
PubMed:	View item in PubMed

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