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| Item Type: | Article |
|---|---|
| Title: | TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src |
| Creators Name: | Wong, B.R., Besser, D., Kim, N., Arron, J.R., Vologodskaia, M., Hanafusa, H. and Choi, Y. |
| Abstract: | TRANCE, a TNF family member, and its receptor, TRANCE-R, are critical regulators of dendritic cell and osteoclast function. Here, we demonstrate that TRANCE activates the antiapoptotic serine/threonine kinase Akt/PKB through a signaling complex involving c-Src and TRAF6. A deficiency in c-Src or addition of Src family kinase inhibitors blocks TRANCE-mediated PKB activation in osteoclasts. c-Src and TRAF6 interact with each other and with TRANCE-R upon receptor engagement. TRAF6, in turn, enhances the kinase activity of c-Src leading to tyrosine phosphorylation of downstream signaling molecules such as c-Cbl. These results define a mechanism by which TRANCE activates Src family kinases and PKB and provide evidence of cross-talk between TRAF proteins and Src family kinases. |
| Keywords: | Carrier Proteins, Cultured Cells , Dendritic Cells, Membrane Glycoproteins, Osteoclasts, Protein-Serine-Threonine Kinases, Protein-Tyrosine Kinases, Proteins, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-akt, RANK Ligand, Tumor Necrosis Factor Receptors, Signal Transduction, TNF Receptor-Associated Factor 6, Tumor Necrosis Factor-alpha, Animals |
| Source: | Molecular Cell |
| ISSN: | 1097-2765 |
| Publisher: | Cell Press |
| Volume: | 4 |
| Number: | 6 |
| Page Range: | 1041-1049 |
| Date: | December 1999 |
| Official Publication: | https://doi.org/10.1016/S1097-2765(00)80232-4 |
| PubMed: | View item in PubMed |
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