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Neurodegeneration in autoimmune demyelination: recent mechanistic insights reveal novel therapeutic targets

Item Type:Review
Title:Neurodegeneration in autoimmune demyelination: recent mechanistic insights reveal novel therapeutic targets
Creators Name:Aktas, O. and Waiczies, S. and Zipp, F.
Abstract:Multiple sclerosis (MS) is the most common chronic demyelinating disease of the central nervous system (CNS) and the major cause of neurological disability in young adults in Western countries. In spite of intensive research efforts, treatment options established to date do not sufficiently prevent the accumulation of tissue damage and clinical disability in patients with MS. We here describe recently identified molecules responsible for the inflammatory and the neurodegenerative processes in MS and its animal model, experimental autoimmune encephalomyelitis (EAE), and review new treatment options targeting both aspects of this disease.
Keywords:MS, EAE, Neuronal damage, HMG-CoA reductase, EGCG, TRAIL, Animals
Source:Journal of Neuroimmunology
ISSN:0165-5728
Publisher:Elsevier (The Netherlands)
Volume:184
Number:1-2
Page Range:17-26
Date:March 2007
Official Publication:https://doi.org/10.1016/j.jneuroim.2006.11.026
PubMed:View item in PubMed

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