Striking back at the activator: how IkappaB kinase terminates antigen receptor responses

Item Type:	Article
Title:	Striking back at the activator: how IkappaB kinase terminates antigen receptor responses
Creators Name:	Hinz, M. and Scheidereit, C.
Abstract:	Antigen recognition by the T cell receptor (TCR) elicits several intracellular signaling cascades, one of which activates the transcription factor NF-kappaB through IkappaB kinases (IKK). NF-kappaB regulates lymphocyte differentiation, proliferation, and apoptosis; thus, tight temporal control of its activation is required to prevent harmful immune cell dysregulation. Although considerable insight into the IKK and NF-kappaB activation process has emerged, less is known about the temporal regulation and termination of immunoreceptor signaling. Two recent studies have revealed that the scaffold protein Bcl10--which, together with CARMA1 and Malt1, forms the TCR-induced IKK-activating CBM complex--is a negative feedback substrate for IKK. IKKbeta initially contributes to CBM formation--which is required for full IKK activation--and then, through carboxyl-terminal Bcl10 phosphorylation, disrupts this structure to terminate signaling. IKK triggers Bcl10 degradation by the ubiquitin-proteasome system through phosphorylation of Bcl10 at other sites. Thus, inactivation through negative feedback mechanisms is an intrinsic property of the TCR-induced NF-kappaB pathway.
Keywords:	Enzyme Activation, I-kappa B Kinase, Phosphorylation, Substrate Specificity, T-Cell Antigen Receptors, Animals
Source:	Science's STKE Signal Transduction Knowledge Environment
ISSN:	1525-8882
Publisher:	American Association for the Advancement of Science
Volume:	384
Page Range:	pe19
Date:	1 May 2007
Official Publication:	https://doi.org/10.1126/stke.3842007pe19
PubMed:	View item in PubMed

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