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| Item Type: | Article |
|---|---|
| Title: | Der Riesenzelltumor des Knochens : Eine Analyse von 87 Patienten [Giant cell tumor of bone. An evaluation of 87 patients] |
| Creators Name: | Tunn, P.U. and Schlag, P.M. |
| Abstract: | Aim: Giant cell tumor (GCT) of bone is a very peculiar and interesting tumor due to of its biological behavior and the phenomenon of pulmonary metastases of a histologically benign tumor. We present the results of a retrospective study. Methods: Between 1965 and 2002 we treated 87 patients, 54 women and 33 men, for a GCT of bone. The average age of the patients was 28.2 (range 8 - 72) years. The median follow-up time was 91 months. 63 patients (72.4 %) were hospitalized with a primary tumor. Twelve of these patients (19 %) had a pathological fracture. 24 patients (27.6 %) presented with local recurrence. 7 tumors were malignant GCT of bone, 80 tumors were benign. According to the classification of Campanacci, 9 patients (10.3 %) were diagnosed in stage I, 42 (48.3 %) in stage II, and 36 (41.4 %) in stage III. Surgical procedures were intralesional curettage and packing with cement in 36 patients, and bone-grafting in 7. In 35 cases we performed a wide resection, and in nine an amputation. Results: Local recurrence was observed in 11 patients (12.6 %), all of them were benign GCT. Local recurrences were followed by an intralesional curettage and bone-grafting in three cases (42.8 %), packing with cement in seven (19.4 %). Three patients with local recurrence (27.3 %) also had synchronous pulmonary metastases. All patients diagnosed with benign GCT are still alive. 3 out of 7 patients with malignant GCT died from progression of metastatic disease. Conclusion: To reduce the risk of local recurrence and pulmonary metastases, we recommend an adjuvant therapy of GCT. |
| Keywords: | Giant Cell Tumor, Surgical Treatment, Local Recurrence, Pulmonary Metastases |
| Source: | Zeitschrift fuer Orthopaedie und Ihre Grenzgebiete |
| ISSN: | 0044-3220 |
| Volume: | 141 |
| Number: | 6 |
| Page Range: | 690-698 |
| Date: | November 2003 |
| Official Publication: | https://doi.org/10.1055/s-2003-812400 |
| PubMed: | View item in PubMed |
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