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| Item Type: | Article |
|---|---|
| Title: | Cloning of two novel human importin alpha subunits and analysis of the expression pattern of the importin-alpha protein family |
| Creators Name: | Koehler, M. and Ansieau, S. and Prehn, S. and Leutz, A. and Haller, H. and Hartmann, E. |
| Abstract: | The import of many proteins into the nucleus is mediated by the importin-alpha/beta heterodimer. While only one importin-beta gene has been found, several forms of importin-alpha have been described. In addition to the three human importin-alphas already identified, we report here the primary structure of two new human importin-alpha proteins. The five known human importin-alpha subunits can be classified into three subfamilies that appear conserved in higher eukaryotic organisms. We show by immunoblotting that the different importin-alpha subfamilies are expressed in a variety of human tissues and mammalian cell lines. |
| Keywords: | Nuclear Transport, Importin-{alpha}, Protein Expression, Nuclear Signaling, Animals, Rabbits |
| Source: | FEBS Letters |
| ISSN: | 0014-5793 |
| Publisher: | Elsevier |
| Volume: | 417 |
| Number: | 1 |
| Page Range: | 104-108 |
| Date: | 3 November 1997 |
| Official Publication: | https://doi.org/10.1016/S0014-5793(97)01265-9 |
| PubMed: | View item in PubMed |
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