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| Item Type: | Dataset |
|---|---|
| Title: | Complex Human Hair Bearing Skin Organoids Reveal Cell-Type Specific Susceptibility and Innate Immune Responses to Herpes Simplex Virus 1 |
| Creators: |
Wyler, E.  ORCID: https://orcid.org/0000-0002-9884-1806, Albertini, S., Friedel, C.C., Manukyan, A. ORCID: https://orcid.org/0000-0002-0441-9517, Winterfeldt, A., Bracker, N., Huang, J., Krasemann, S., Plumbom, I. ORCID: https://orcid.org/0009-0006-3720-3700, Altmüller, J. ORCID: https://orcid.org/0000-0003-4372-1521, Conrad, T. ORCID: https://orcid.org/0000-0001-5618-6295, Reimer, R., Schneider, C., Radbruch, H. ORCID: https://orcid.org/0000-0001-6941-3397, Hafezi, W., Hansen, A., Grundhoff, A., Landthaler, M. ORCID: https://orcid.org/0000-0002-1075-8734, Fischer, N. and Czech-Sioli, M.
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| Abstract: | Epithelial surfaces are the initial site of Herpes Simplex Virus 1 (HSV-1) infection. To reflect the complexity of human skin, we used complex human hair bearing skin organoids as a new model system for HSV-1 infection. Using microscopy and spatial transcriptomics with single cell resolution, we characterize the progression of infection through the tissue as well as host cell responses. |
| Source: | Gene Expression Omnibus (GEO) |
| Publisher: | National Center for Biotechnology Information (NCBI) |
| Date: | 24 September 2026 |
| External Fulltext: | View full text on external repository or document server |
| Related to: |
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