Micronuclear ecDNA constrains tumor cell fitness and is associated with favorable patient survival

Brückner, Lotte; Xu, Robin; Tang, Jun; Gnanasekar, Aditi; Herrmann, Alexander; Wong, Ivy Tsz-Lo; Zhang, Shu; Tu, Fengyu; Pilon, Madison; Kukalev, Alexander; Pardon, Katharina; Sidorova, Olga; Atta, Joshua; Yu, Qinghao; Montouri, Giulia; Pradella, Davide; Ilić, Mila; Suina, Kentaro; Novais-Cruz, Marco; Kaltenbach, Sarah; Treue, Denise; Giurgiu-Kraljič, Mădălina; Herzog, Sergej; Hollinger, Ann-Sophie; Wittstruck, Nadine; Fernandez, Martina; Wolozyn, Nicole; Becker, Finnja; Louma, Varvara-Rigina; Yan, Xiaowei; Schmargon, Rachel; Dörr, Jan R.; Gamlin, David; Lehmann, Annika; Gürgen, Dennis; Richter, Matthias; Dubois, Frank; Simeoni, Fabrizio; Pennycook, Betheney R.; Hamilton, Alastair; Lindemann, Ralph K.; Dawes, Courtney; Balmus, Gabriel; Hero, Barbara; Fischer, Matthias; Bafna, Vineet; Verhaak, Roel; Wahl, Geoffrey; Liu, Yang; Koche, Richard P.; Papathanasiou, Stamatis; Medema, René; Spanjaard, Bastiaan; Ventura, Andrea; Pombo, Ana; Huang, Weini; Scheer, Monika; Werner, Benjamin; Chang, Howard Y.; Mischel, Paul S.; Henssen, Anton G.

Micronuclear ecDNA constrains tumor cell fitness and is associated with favorable patient survival

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Item Type:	Article
Title:	Micronuclear ecDNA constrains tumor cell fitness and is associated with favorable patient survival
Creators:	Brückner, Lotte ORCID: https://orcid.org/0000-0002-6155-2277, Xu, Robin ORCID: https://orcid.org/0000-0002-5618-246X, Tang, Jun ORCID: https://orcid.org/0009-0004-4606-2458, Gnanasekar, Aditi, Herrmann, Alexander ORCID: https://orcid.org/0009-0002-7700-6788, Wong, Ivy Tsz-Lo ORCID: https://orcid.org/0000-0002-9761-3422, Zhang, Shu ORCID: https://orcid.org/0000-0003-2543-5943, Tu, Fengyu ORCID: https://orcid.org/0000-0001-8748-7250, Pilon, Madison ORCID: https://orcid.org/0000-0001-9060-4817, Kukalev, Alexander ORCID: https://orcid.org/0000-0001-5847-3773, Pardon, Katharina, Sidorova, Olga ORCID: https://orcid.org/0009-0004-1459-1662, Atta, Joshua, Yu, Qinghao ORCID: https://orcid.org/0000-0002-2151-9624, Montouri, Giulia, Pradella, Davide ORCID: https://orcid.org/0000-0002-8649-7817, Ilić, Mila ORCID: https://orcid.org/0000-0003-4664-9393, Suina, Kentaro, Novais-Cruz, Marco, Kaltenbach, Sarah, Treue, Denise, Giurgiu-Kraljič, Mădălina ORCID: https://orcid.org/0000-0001-5007-7442, Herzog, Sergej, Hollinger, Ann-Sophie, Wittstruck, Nadine ORCID: https://orcid.org/0009-0000-4378-3226, Fernandez, Martina, Wolozyn, Nicole, Becker, Finnja ORCID: https://orcid.org/0009-0003-7014-7307, Louma, Varvara-Rigina, Yan, Xiaowei ORCID: https://orcid.org/0000-0002-4846-8812, Schmargon, Rachel ORCID: https://orcid.org/0009-0009-3535-7185, Dörr, Jan R. ORCID: https://orcid.org/0000-0002-4927-6548, Gamlin, David, Lehmann, Annika, Gürgen, Dennis ORCID: https://orcid.org/0000-0001-9241-6537, Richter, Matthias ORCID: https://orcid.org/0000-0002-5339-0781, Dubois, Frank ORCID: https://orcid.org/0000-0002-7654-6208, Simeoni, Fabrizio ORCID: https://orcid.org/0000-0002-5543-6413, Pennycook, Betheney R., Hamilton, Alastair, Lindemann, Ralph K., Dawes, Courtney, Balmus, Gabriel ORCID: https://orcid.org/0000-0003-2872-4468, Hero, Barbara ORCID: https://orcid.org/0000-0003-4129-890X, Fischer, Matthias ORCID: https://orcid.org/0000-0003-1363-1242, Bafna, Vineet ORCID: https://orcid.org/0000-0002-5810-6241, Verhaak, Roel ORCID: https://orcid.org/0000-0003-2773-0436, Wahl, Geoffrey ORCID: https://orcid.org/0000-0003-3658-2279, Liu, Yang ORCID: https://orcid.org/0000-0002-3889-9707, Koche, Richard P. ORCID: https://orcid.org/0000-0002-6820-5083, Papathanasiou, Stamatis ORCID: https://orcid.org/0000-0001-6969-044X, Medema, René, Spanjaard, Bastiaan ORCID: https://orcid.org/0000-0003-1309-8839, Ventura, Andrea ORCID: https://orcid.org/0000-0003-4320-9907, Pombo, Ana ORCID: https://orcid.org/0000-0002-7493-6288, Huang, Weini ORCID: https://orcid.org/0000-0002-9016-2665, Scheer, Monika, Werner, Benjamin ORCID: https://orcid.org/0000-0002-6857-8699, Chang, Howard Y. ORCID: https://orcid.org/0000-0002-9459-4393, Mischel, Paul S. ORCID: https://orcid.org/0000-0002-4560-2211 and Henssen, Anton G. ORCID: https://orcid.org/0000-0003-1534-778X
Source:	Nature Genetics
ISSN:	1061-4036
Publisher:	Nature Publishing Group
Date:	12 October 2026
Official Publication:	https://doi.org/10.1038/s41588-026-02782-w
PubMed:	View item in PubMed
Related to:	URL URL Type https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-16933?query=E-MTAB-16933 External Dataset https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-16944?query=E-MTAB-16944 External Dataset https://www.ebi.ac.uk/ena/browser/view/PRJEB112294 External Dataset https://www.ebi.ac.uk/ena/browser/view/PRJEB111610 External Dataset https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE90683 External Dataset https://github.com/henssen-lab/ecDNA_microncleus/ Software https://doi.org/10.5281/zenodo.21207200 Software

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