![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Tools
Tools
Preview |
PDF (Original Article)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
3MB |
![[thumbnail of Supporting Information]](https://edoc.mdc-berlin.de/style/images/fileicons/other.png) |
Other (Supporting Information)
1MB |
| Item Type: | Article |
|---|---|
| Title: | Association of altered body composition with cardiac wasting in cancer with and without cardiotoxic therapy |
| Creators: |
Hadzibegovic, Sara  ORCID: https://orcid.org/0000-0002-8481-337X, Hella, Jonathan L., Porthun, Jan ORCID: https://orcid.org/0000-0002-4100-4361, Lena, Alessia ORCID: https://orcid.org/0000-0002-1550-7870, Krug, Danara, Baluta, Iulia, Wilkenshoff, Ursula ORCID: https://orcid.org/0009-0007-6058-2259, Mahabadi, Amir A. ORCID: https://orcid.org/0000-0003-2336-7991, Totzeck, Matthias ORCID: https://orcid.org/0000-0001-5574-948X, Rassaf, Tienush ORCID: https://orcid.org/0000-0001-8001-0265, Anker, Stefan D. ORCID: https://orcid.org/0000-0002-0805-8683, Doehner, Wolfram ORCID: https://orcid.org/0000-0001-7598-708X, Keller, Ulrich ORCID: https://orcid.org/0000-0002-8485-1958, Bullinger, Lars ORCID: https://orcid.org/0000-0002-5890-5510, Modest, Dominik P. ORCID: https://orcid.org/0000-0002-6853-0599, Laird, Barry J.A. ORCID: https://orcid.org/0000-0002-2807-6192, Skipworth, Richard J.E. ORCID: https://orcid.org/0000-0003-1428-4078, Cleland, John G.F. ORCID: https://orcid.org/0000-0002-1471-7016, Oeing, Christian ORCID: https://orcid.org/0000-0002-0816-4443, von Haehling, Stephan ORCID: https://orcid.org/0000-0002-0816-4443, Landmesser, Ulf ORCID: https://orcid.org/0000-0002-0214-3203 and Anker, Markus S. ORCID: https://orcid.org/0000-0002-4406-8555
|
| Abstract: | BACKGROUND AND PURPOSE: In advanced cancer, associations among changes in body composition, cardiac wasting and prior cardiotoxic anticancer therapy have not been investigated. EXPERIMENTAL APPROACH: Using bioelectrical impedance analysis (BIA), body composition was measured in 206 patients with mostly advanced cancer without known cardiovascular disease or infection (stage III/IV: 84%, prior cardiotoxic anticancer therapy: 55%). Left ventricular (LV) mass was assessed by transthoracic echocardiography and grouped by presence of cardiac wasting according to previously established sex-specific thresholds for LV mass adjusted for height2 (<61 g/m2 for women, <57 g/m2 for men). BIA measurements (indexed to height2) included fat mass index (FMI), fat-free mass index (FFMI), skeletal muscle mass index (SMMI), visceral fat index (VFI), total body water index (TBWI) and extracellular water index (ECWI). KEY RESULTS: Patients with cancer and cardiac wasting (n = 88) were younger (57±15 vs 62±13 years) and more often women (68% vs 29%) compared to those without cardiac wasting (n = 118). Patients with cardiac wasting had significantly lower FMI (-12%), FFMI (-14%), SMMI (-16%), VFI (-46%), TBWI (-13%) and ECWI (-14%). For women, FFMI was significantly associated with LV mass/height2 (r = 0.41) and VFI for men (r = 0.40). In the multivariable linear regression analysis, FFMI was the strongest significant predictor of cardiac wasting, with no significant interaction by sex or previous cardiotoxic therapy. CONCLUSIONS AND IMPLICATIONS: Cardiac wasting in advanced cancer is associated with lower FFMI and VFI independent of prior cardiotoxic therapy. |
| Keywords: | Cardiotoxicity, Cachexia, Cancer, Cardiology, Echocardiography, Left Ventricular Mass |
| Source: | British Journal of Pharmacology |
| ISSN: | 0007-1188 |
| Publisher: | Wiley |
| Date: | 7 October 2026 |
| Official Publication: | https://doi.org/10.1111/bph.70639 |
| PubMed: | View item in PubMed |
Repository Staff Only: item control page
