Senescence and cancer - role and therapeutic opportunities

Item Type:	Review
Title:	Senescence and cancer - role and therapeutic opportunities
Creators Name:	Schmitt, C.A. and Wang, B. and Demaria, M.
Abstract:	Cellular senescence is a state of stable, terminal cell cycle arrest associated with various macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells into senescence can act as a barrier to tumorigenesis and, thus, could in principle constitute a desired outcome for any anticancer therapy. Paradoxically, studies published in the past decade have demonstrated that, in certain conditions and contexts, malignant and non-malignant cells with lastingly persistent senescence can acquire pro-tumorigenic properties. In this Review, we first discuss the major mechanisms involved in the antitumorigenic functions of senescent cells and then consider the cell-intrinsic and cell-extrinsic factors that participate in their switch towards a tumour-promoting role, providing an overview of major translational and emerging clinical findings. Finally, we comprehensively describe various senolytic and senomorphic therapies and their potential to benefit patients with cancer.
Keywords:	Cancer, Cell Biology
Source:	Nature Reviews Clinical oncology
ISSN:	1759-4774
Publisher:	Nature Publishing Group
Volume:	19
Number:	10
Page Range:	619–636
Date:	October 2022
Additional Information:	Copyright © 2022 Springer Nature Limited.
Official Publication:	https://doi.org/10.1038/s41571-022-00668-4
External Fulltext:	View full text on PubMed Central
PubMed:	View item in PubMed

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