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Simultaneous dimensionality reduction and integration for single-cell ATAC-seq data using deep learning

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Item Type:Article
Title:Simultaneous dimensionality reduction and integration for single-cell ATAC-seq data using deep learning
Creators Name:Kopp, W., Akalin, A. and Ohler, U.
Abstract:Advances in single-cell technologies enable the routine interrogation of chromatin accessibility for tens of thousands of single cells, elucidating gene regulatory processes at an unprecedented resolution. Meanwhile, size, sparsity and high dimensionality of the resulting data continue to pose challenges for its computational analysis, and specifically the integration of data from different sources. We have developed a dedicated computational approach: a variational auto-encoder using a noise model specifically designed for single-cell ATAC-seq (assay for transposase-accessible chromatin with high-throughput sequencing) data, which facilitates simultaneous dimensionality reduction and batch correction via an adversarial learning strategy. We showcase its benefits for detailed cell-type characterization on individual real and simulated datasets as well as for integrating multiple complex datasets.
Keywords:Computational Models, Data Integration, Machine Learning
Source:Nature Machine Intelligence
ISSN:2522-5839
Publisher:Springer Nature
Volume:4
Number:2
Page Range:162-168
Date:February 2022
Official Publication:https://doi.org/10.1038/s42256-022-00443-1

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