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| Item Type: | Article |
|---|---|
| Title: | How to find genomic regions relevant for gene regulation |
| Creators Name: | Guo, X. and Ohler, U. and Yildirim, F. |
| Abstract: | Genetic variants associated with human diseases are often located outside the protein coding regions of the genome. Identification and functional characterization of the regulatory elements in the non-coding genome is therefore of crucial importance for understanding the consequences of genetic variation and the mechanisms of disease. The past decade has seen rapid progress in high-throughput analysis and mapping of chromatin accessibility, looping, structure, and occupancy by transcription factors, as well as epigenetic modifications, all of which contribute to the proper execution of regulatory functions in the non-coding genome. Here, we review the current technologies for the definition and functional validation of non-coding regulatory regions in the genome. |
| Keywords: | Non-Coding Genome, cis-Regulatory Regions, Transcriptional Regulation, Epigenetics, Transcription Factor Binding |
| Source: | Medizinische Genetik |
| ISSN: | 0936-5931 |
| Publisher: | de Gruyter |
| Volume: | 33 |
| Number: | 2 |
| Page Range: | 157-165 |
| Date: | 14 August 2021 |
| Official Publication: | https://doi.org/10.1515/medgen-2021-2074 |
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