PiggyBac transposable element-derived 1 controls neuronal progenitor identity, stress sensing and mammal-specific paraspeckles

Item Type:

Preprint

Title:

Creators Name:

Raskó, T. and Pande, A. and Radscheit, K. and Zink, A. and Singh, M. and Sommer, C. and Wachtl, G. and Kolacsek, O. and Inak, G. and Szvetnik, A. and Petrakis, S. and Bunse, M. and Bansal, V. and Selbach, M. and Orbán, T. and Prigione, A. and Hurst, L.D. and Izsvák, Z.

Abstract:

The evolution and functional integration of new genes, especially those that become core to key functions, remains enigmatic. We consider the mammal-specific gene, piggyBac transposable element derived 1 (PGBD1), implicated in neuronal disorders. While it no longer recognises piggyBac transposon-like inverted repeats and transposase functionality having been lost, it has evolved a core role in neural homeostasis. Depletion of PGBD1 triggers accumulation of mammal-specific paraspeckles and neural differentiation. It acts by two modalities, DNA binding and protein-protein interaction. As a transcriptional repressor of (lnc)NEAT1, the backbone of paraspeckles, it inhibits paraspeckle formation in neural progenitor cells (NPCs). At the protein level it is associated with the stress response system, a function partially shared with (lnc)NEAT1. PGBD1 thus presents as an unusual exemplar of new gene creation, being a recently acquired multi-function, multi-modal gene. Mammalian specificity associated with control of a mammal-specific structure implies coevolution of new genes with new functions.

Source:

bioRxiv

Publisher:

Cold Spring Harbor Laboratory Press

Article Number:

2021.05.19.444448

Date:

19 May 2021

Official Publication:

https://doi.org/10.1101/2021.05.19.444448

Related to:

URL	URL Type
https://edoc.mdc-berlin.de/22166/	Final version

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