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| Item Type: | Article |
|---|---|
| Title: | Subiculum as a generator of sharp wave-ripples in the rodent hippocampus |
| Creators Name: | Imbrosci, B. and Nitzan, N. and McKenzie, S. and Donoso, J.R. and Swaminathan, A. and Böhm, C. and Maier, N and Schmitz, D. |
| Abstract: | Sharp wave-ripples (SWRs) represent synchronous discharges of hippocampal neurons and are believed to play a major role in memory consolidation. A large body of evidence suggests that SWRs are exclusively generated in the CA3-CA2 network. In contrast, here, we provide several lines of evidence showing that the subiculum can function as a secondary SWRs generator. SWRs with subicular origin propagate forward into the entorhinal cortex as well as backward into the hippocampus proper. Our findings suggest that the output structures of the hippocampus are not only passively facilitating the transfer of SWRs to the cortex, but they also can actively contribute to the genesis of SWRs. We hypothesize that SWRs with a subicular origin may be important for the consolidation of information conveyed to the hippocampus via the temporoammonic pathway. |
| Keywords: | Hippocampus, CA3, CA1, Subiculum, Entorhinal Cortex, Oscillations, Sharp Wave-Ripples, Animals, Mice, Rats |
| Source: | Cell Reports |
| ISSN: | 2211-1247 |
| Publisher: | Cell Press / Elsevier |
| Volume: | 35 |
| Number: | 3 |
| Page Range: | 109021 |
| Date: | 20 April 2021 |
| Official Publication: | https://doi.org/10.1016/j.celrep.2021.109021 |
| PubMed: | View item in PubMed |
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