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Monitoring renal hemodynamics and oxygenation by invasive probes: experimental protocol

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Item Type:Article
Title:Monitoring renal hemodynamics and oxygenation by invasive probes: experimental protocol
Creators Name:Cantow, K. and Ladwig-Wiegard, M. and Flemming, B. and Pohlmann, A. and Niendorf, T. and Seeliger, E.
Abstract:Renal tissue hypoperfusion and hypoxia are early key elements in the pathophysiology of acute kidney injury of various origins, and may also promote progression from acute injury to chronic kidney disease. Here we describe methods to study control of renal hemodynamics and tissue oxygenation by means of invasive probes in anesthetized rats. Step-by-step protocols are provided for two setups, one for experiments in laboratories for integrative physiology and the other for experiments within small-animal magnetic resonance scanners.This publication is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This experimental protocol chapter is complemented by a separate chapter describing the basic concepts of quantitatively assessing renal perfusion and oxygenation with invasive probes.
Keywords:Renal Hemodynamics and Oxygenation, In Vivo Methods, Magnetic Resonance Imaging (MRI), Animals, Rats
Source:Methods in Molecular Biology
Series Name:Methods in Molecular Biology
Title of Book:Preclinical MRI of the kidney : methods and protocols
ISSN:1064-3745
ISBN:978-1-0716-0977-4
Publisher:Springer / Humana Press
Volume:2216
Page Range:327-347
Date:2021
Official Publication:https://doi.org/10.1007/978-1-0716-0978-1_19
PubMed:View item in PubMed
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https://edoc.mdc-berlin.de/19922/Book

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