Stress CMR in patients with obesity: insights from the Stress CMR Perfusion Imaging in the United States (SPINS) registry

Item Type:	Article
Title:	Stress CMR in patients with obesity: insights from the Stress CMR Perfusion Imaging in the United States (SPINS) registry
Creators Name:	Ge, Y. and Steel, K. and Antiochos, P. and Bingham, S. and Abdullah, S. and Mikolich, J.R. and Arai, A.E. and Bandettini, W.P. and Shanbhag, S.M. and Patel, A.R. and Farzaneh-Far, A. and Heitner, J.F. and Shenoy, C. and Leung, S.W. and Gonzalez, J.A. and Shah, D.J. and Raman, S.V. and Nawaz, H. and Ferrari, V.A. and Schulz-Menger, J. and Stuber, M. and Simonetti, O.P. and Kwong, R.Y.
Abstract:	AIMS: Non-invasive assessment and risk stratification of coronary artery disease in patients with large body habitus is challenging. We aim to examine whether body mass index (BMI) modifies the prognostic value and diagnostic utility of stress cardiac magnetic resonance imaging (CMR) in a multicentre registry. METHODS AND RESULTS: The SPINS Registry enrolled consecutive intermediate-risk patients who presented with a clinical indication for stress CMR in the USA between 2008 and 2013. Baseline demographic data including BMI, CMR indices, and ratings of study quality were collected. Primary outcome was defined by a composite of cardiovascular death and non-fatal myocardial infarction. Of the 2345 patients with available BMI included in the SPINS cohort, 1177 (50%) met criteria for obesity (BMI ≥ 30) with 531 (23%) at or above Class 2 obesity (BMI ≥ 35). In all BMI categories, >95% of studies were of diagnostic quality for cine, perfusion, and late gadolinium enhancement (LGE) sequences. At a median follow-up of 5.4 years, those without ischaemia and LGE experienced a low annual rate of hard events (<1%), across all BMI strata. In patients with obesity, both ischaemia [hazard ratio (HR): 2.14; 95% confidence interval (CI): 1.30-3.50; P = 0.003] and LGE (HR: 3.09; 95% CI: 1.83-5.22; P < 0.001) maintained strong adjusted association with the primary outcome in a multivariable Cox regression model. Downstream referral rates to coronary angiography, revascularization, and cost of care spent on ischaemia testing did not significantly differ within the BMI categories. CONCLUSION: In this large multicentre registry, elevated BMI did not negatively impact the diagnostic quality and the effectiveness of risk stratification of patients referred for stress CMR.
Keywords:	Contrast Media, Gadolinium, Magnetic Resonance Imaging, Cine Magnetic Resonance Imaging, Obesity, Perfusion Imaging, Predictive Value of Tests, Prognosis, Registries, United States
Source:	European Heart Journal - Cardiovascular Imaging
ISSN:	2047-2404
Publisher:	Oxford University Press
Volume:	22
Number:	5
Page Range:	518-527
Date:	May 2021
Additional Information:	Copyright: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020. For permissions, please email: journals.permissions@oup.com. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)
Official Publication:	https://doi.org/10.1093/ehjci/jeaa281
External Fulltext:	View full text on PubMed Central
PubMed:	View item in PubMed

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