Soluble (pro)renin receptor in elderly chronic heart failure patients

Item Type:	Article
Title:	Soluble (pro)renin receptor in elderly chronic heart failure patients
Creators Name:	Obradovic, D. and Loncar, G. and Radenovic, S. and Tahirovic, E. and Heidecke, H. and Schulze-Forster, K. and Muller, D. and Busjahn, A. and Buttner, P. and Veskovic, J. and Zdravkovic, M. and Li, H. and Li, S. and Savkovic, V. and Pieske, B. and Dungen, H.D. and Dechend, R.
Abstract:	Overactivation of renin-angiotensin system (RAS) is one of the main pathophysiological features in the evolution of chronic heart failure (CHF). The (pro)renin receptor ((P)RR) represents an important player in a tissue renin-angiotensin system (tissue RAS), which mediates tissue injury through fibrosis and hypertrophy of the affected organs in CHF patients. In our study we used plasma samples from 556 elderly subjects with CHF and 198 healthy participants in order to evaluate prognostic and diagnostic potential of s(P)RR in setting of CHF. The patients with CHF showed significantly higher plasma levels of s(P)RR than the healthy volunteers (p=0.0005). We observed association between higher s(P)RR plasma concentrations and lower left ventricular ejection fraction and higher degree of left ventricular dilatation on baseline echocardiography examination of the CHF patients. Elderly CHF patients with higher baseline s(P)RR plasma concentration were at same risk for death, stroke and hospitalization due to heart failure worsening at mean follow-up from forty-eight months in comparison to low s(P)RR counterparts.
Keywords:	Chronic Heart Failure, Soluble (Pro)Renin Receptor, Left Ventricular Ejection Fraction, Left Ventricular Remodeling
Source:	Frontiers in Bioscience-Landmark
ISSN:	1093-9946
Publisher:	Frontiers in Bioscience
Volume:	25
Page Range:	1839-1853
Date:	1 June 2020
Official Publication:	https://doi.org/10.2741/4880
PubMed:	View item in PubMed

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