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| Item Type: | Article |
|---|---|
| Title: | Diabetes, but not hypertension and obesity, is associated with postoperative cognitive dysfunction |
| Creators Name: | Lachmann, G. and Feinkohl, I. and Borchers, F. and Ottens, T.H. and Nathoe, H.M. and Sauer, A.M. and Dieleman, J.M. and Radtke, F.M. and van Dijk, D. and Spies, C. and Pischon, T. |
| Abstract: | BACKGROUND/AIMS: Older people undergoing surgery are at risk of developing postoperative cognitive dysfunction (POCD), but little is known of risk factors predisposing patients to POCD. Our objective was to estimate the risk of POCD associated with exposure to preoperative diabetes, hypertension, and obesity. METHODS: Original data from 3 randomised controlled trials (OCTOPUS, DECS, SuDoCo) were obtained for secondary analysis on diabetes, hypertension, baseline blood pressure, obesity (BMI ≥30 kg/m(2)), and BMI as risk factors for POCD in multiple logistic regression models. Risk estimates were pooled across the 3 studies. RESULTS: Analyses totalled 1,034 patients. POCD occurred in 5.2% of patients in DECS, in 9.4% in SuDoCo, and in 32.1% of patients in OCTOPUS. After adjustment for age, sex, surgery type, randomisation, obesity, and hypertension, diabetes was associated with a 1.84-fold increased risk of POCD (OR 1.84; 95% CI 1.14, 2.97; p = 0.01). Obesity, BMI, hypertension, and baseline blood pressure were each not associated with POCD in fully adjusted models (all p > 0.05). CONCLUSION: Diabetes, but not obesity or hypertension, is associated with increased POCD risk. Consideration of diabetes status may be helpful for risk assessment of surgical patients. |
| Keywords: | Diabetes, Hypertension, Obesity, Postoperative Cognitive Dysfunction |
| Source: | Dementia and Geriatric Cognitive Disorders |
| ISSN: | 1420-8008 |
| Publisher: | Karger |
| Volume: | 46 |
| Number: | 3-4 |
| Page Range: | 193-206 |
| Date: | 16 October 2018 |
| Additional Information: | Copyright © 2018 S. Karger AG, Basel |
| Official Publication: | https://doi.org/10.1159/000492962 |
| PubMed: | View item in PubMed |
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