Estrus-cycle regulation of cortical inhibition
| Item Type: | Preprint |
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| Title: | Estrus-cycle regulation of cortical inhibition |
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| Creators Name: | Clemens, A.M. and Lenschow, C. and Beed, P. and Li, L. and Sammons, R. and Naumann, R.K. and Wang, H. and Schmitz, D. and Brecht, M. |
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| Abstract: | Female mammals experience cyclical changes in sexual receptivity known as the estrus-cycle. Little is known about how estrus affects the cortex although alterations in sensation, cognition and the cyclic occurrence of epilepsy suggest brain-wide processing changes. We performed in vivo juxtacellular and whole-cell recordings in somatosensory cortex of female rats and found that the estrus-cycle potently altered cortical inhibition. Fast-spiking interneurons strongly varied their activity with the estrus-cycle and estradiol in ovariectomized females, while regular-spiking excitatory neurons did not change. In vivo whole-cell recordings revealed a varying excitation-to-inhibition-ratio with estrus. In situ hybridization for estrogen receptor β (Esr2) showed co-localization with parvalbumin-positive interneurons in deep cortical layers, mirroring the laminar distribution of our physiological findings. In vivo and in vitro experiments confirmed that estrogen acts locally to increase fast-spiking interneuron excitability through an estrogen receptor β mechanism. We conclude that sex hormones powerfully modulate cortical inhibition in the female brain. |
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| Source: | bioRxiv |
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| Publisher: | Cold Spring Harbor Laboratory Press |
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| Article Number: | 314641 |
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| Date: | 5 May 2018 |
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| Official Publication: | https://doi.org/10.1101/314641 |
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| Related to: | |
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