Brain serotonin critically contributes to the biological effects of electroconvulsive seizures

Item Type:	Article
Title:	Brain serotonin critically contributes to the biological effects of electroconvulsive seizures
Creators Name:	Kronenberg, G. and Petermann, M. and Dormann, C. and Bader, M. and Gass, P. and Hellweg, R. and Klempin, F.
Abstract:	Compounds targeting serotonin (5-HT) are widely used as antidepressants. However, the role of 5-HT in mediating the effects of electroconvulsive seizure (ECS) therapy remains undefined. Using Tph2(-/-) mice depleted of brain 5-HT, we studied the effects of ECS on behavior and neurobiology. ECS significantly prolonged the start latency in the elevated O-Maze test, an effect that was abolished in Tph2(-/-) mice. Furthermore, in the absence of 5-HT, the ECS-induced increase in adult neurogenesis and in brain-derived neurotrophic factor signaling in the hippocampus were significantly reduced. Our results indicate that brain 5-HT critically contributes to the neurobiological responses to ECS.
Keywords:	Neurogenesis, BDNF, TPH2, Depression, Antidepressants, Animals, Mice
Source:	European Archives of Psychiatry and Clinical Neuroscience
ISSN:	0940-1334
Publisher:	Springer / Steinkopff
Volume:	268
Number:	8
Page Range:	861-864
Date:	December 2018
Additional Information:	Copyright© Springer-Verlag GmbH Germany, part of Springer Nature 2018
Official Publication:	https://doi.org/10.1007/s00406-018-0924-0
PubMed:	View item in PubMed

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