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| Item Type: | Article |
|---|---|
| Title: | N-CAM exhibits a regulatory function in pathological angiogenesis in oxygen induced retinopathy |
| Creators Name: | Håkansson, J. and Ståhlberg, A. and Wolfhagen Sand, F. and Gerhardt, H. and Semb, H. |
| Abstract: | Background: Diabetic retinopathy and retinopathy of prematurity are diseases caused by pathological angiogenesis in the retina as a consequence of local hypoxia. The underlying mechanism for epiretinal neovascularization (tuft formation), which contributes to blindness, has yet to be identified. Neural cell adhesion molecule (N-CAM) is expressed by Müller cells and astrocytes, which are in close contact with the retinal vasculature, during normal developmental angiogenesis. Methodology/Principal Findings: Notably, during oxygen induced retinopathy (OIR) N-CAM accumulated on astrocytes surrounding the epiretinal tufts. Here, we show that N-CAM ablation results in reduced vascular tuft formation due to reduced endothelial cell proliferation despite an elevation in VEGFA mRNA expression, whereas retinal developmental angiogenesis was unaffected. Conclusion/Significance: We conclude that N-CAM exhibits a regulatory function in pathological angiogenesis in OIR. This is a novel finding that can be of clinical relevance in diseases associated with proliferative vasculopathy. |
| Keywords: | Cell Proliferation, Diabetic Retinopathy, Endothelial Cells, Hypoxia, Neural Cell Adhesion Molecules, Pathologic Neovascularization, Retinal Neovascularization, Retinal Vessels, Vascular Endothelial Growth Factor A, Animals, Mice |
| Source: | PLoS ONE |
| ISSN: | 1932-6203 |
| Publisher: | Public Library of Science |
| Volume: | 6 |
| Number: | 10 |
| Page Range: | e26026 |
| Date: | 17 October 2011 |
| Official Publication: | https://doi.org/10.1371/journal.pone.0026026 |
| PubMed: | View item in PubMed |
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