|
PDF
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
8MB |
Item Type: | Preprint | ||||
---|---|---|---|---|---|
Title: | Changes in postural syntax characterize sensory modulation and natural variation of C. elegans locomotion | ||||
Creators Name: | Schwarz, R.F. and Branicky, R. and Grundy, L.J. and Schafer, W.R. and Brown, A.E.X. | ||||
Abstract: | Locomotion is driven by shape changes coordinated by the nervous system through time; thus, enumerating an animal's complete repertoire of shape transitions would provide a basis for a comprehensive understanding of locomotor behaviour. Here we introduce a discrete representation of behaviour in the nematode C. elegans. At each point in time, the worm's posture is approximated by its closest matching template from a set of 90 postures and locomotion is represented as sequences of postures. The frequency distribution of postural sequences is heavy-tailed with a core of frequent behaviours and a much larger set of rarely used behaviours. Responses to optogenetic and environmental stimuli can be quantified as changes in postural syntax: worms show different preferences for different sequences of postures drawn from the same set of templates. A discrete representation of behaviour will enable the use of methods developed for other kinds of discrete data in bioinformatics and language processing to be harnessed for the study of behaviour. | ||||
Source: | bioRxiv | ||||
Publisher: | Cold Spring Harbor Laboratory Press | ||||
Article Number: | 017707 | ||||
Date: | 8 April 2015 | ||||
Official Publication: | https://doi.org/10.1101/017707 | ||||
Related to: |
|
Repository Staff Only: item control page