Cardiac morphofunctional characteristics of transgenic rats with overexpression of the bradykinin B1 receptor in the endothelium

Item Type:	Article
Title:	Cardiac morphofunctional characteristics of transgenic rats with overexpression of the bradykinin B1 receptor in the endothelium
Creators Name:	Levy, R.F. and Serra, A.J. and Antonio, E.L. and dos Santos, L. and Bocalini, D.S. and Pesquero, J.B. and Bader, M. and Merino, V.F. and de Oliveira, H.A. and de Arruda Veiga, E.C. and Silva, J.A. and Tucci, P.J.F.
Abstract:	OBJECTIVE: Evaluate whether endothelial overexpressing of the bradykinin B1 receptor could be associated with altered left ventricular and myocardial performance. METHODS: Echocardiography and hemodynamic were employed to assess left ventricular morphology and function in Sprague-Dawley transgenic rats overexpressing the endothelial bradykinin B1 receptor (Tie2B1 rats). The myocardial inotropism was evaluated on papillary muscles contradicting in vitro. RESULTS: In Tie2B1 animals, an enlarged left ventricular cavity and lower fractional shortening coupled with a lower rate of pressure change values indicated depressed left ventricular performance. Papillary muscle mechanics revealed that both Tie2B1 and wild-type rat groups had the same contractile capacities under basal conditions; however, in transgenic animals, there was accentuated inotropism due to post-pause potentiation. Following treatment with the Arg(9)-BK agonist, Tie2B1 papillary muscles displayed a reduction in myocardial inotropism. CONCLUSIONS: Endothelial B1 receptor overexpression has expanded the LV cavity and worsened its function. There was an exacerbated response of papillary muscle in vitro to a prolonged resting pause, and the use of a B1 receptor agonist impairs myocardial inotropism.
Keywords:	Bradykinin Receptor, Cardiac Structure, Cardiac Function, Myocardial Function, Transgenic Rat, Animals, Rats
Source:	Physiological Research
ISSN:	0862-8408
Publisher:	Institute of Physiology, Czech Academy of Sciences
Volume:	66
Number:	6
Page Range:	925-932
Date:	22 September 2017
Official Publication:	http://www.biomed.cas.cz/physiolres/pdf/66/66_925.pdf
PubMed:	View item in PubMed

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