Myocardial effective transverse relaxation time T(2)* correlates with left ventricular wall thickness: a 7.0 T MRI study
Item Type: | Article |
---|
Title: | Myocardial effective transverse relaxation time T(2)* correlates with left ventricular wall thickness: a 7.0 T MRI study |
---|
Creators Name: | Huelnhagen, T. and Hezel, F. and Serradas Duarte, T. and Pohlmann, A. and Oezerdem, C. and Flemming, B. and Seeliger, E. and Prothmann, M. and Schulz-Menger, J. and Niendorf, T. |
---|
Abstract: | PURPOSE: Myocardial effective relaxation time T2* is commonly regarded as a surrogate for myocardial tissue oxygenation. However, it is legitimate to assume that there are multiple factors that influence T2*. To this end, this study investigates the relationship between T2* and cardiac macromorphology given by left ventricular (LV) wall thickness and left ventricular radius, and provides interpretation of the results in the physiological context. METHODS: High spatio-temporally resolved myocardial CINE T2* mapping was performed in 10 healthy volunteers using a 7.0 Tesla (T) full-body MRI system. Ventricular septal wall thickness, left ventricular inner radius, and T2* were analyzed. Macroscopic magnetic field changes were elucidated using cardiac phase-resolved magnetic field maps. RESULTS: Ventricular septal T2* changes periodically over the cardiac cycle, increasing in systole and decreasing in diastole. Ventricular septal wall thickness and T2* showed a significant positive correlation, whereas the inner LV radius and T2* were negatively correlated. The effect of macroscopic magnetic field gradients on T2* can be considered minor in the ventricular septum. CONCLUSION: Our findings suggest that myocardial T2* is related to tissue blood volume fraction. Temporally resolved T2* mapping could be beneficial for myocardial tissue characterization and for understanding cardiac (patho)physiology in vivo. |
---|
Keywords: | Magnetic Resonance Imaging, Cardiac Imaging, Ultrahigh Field MR, Myocardial Tissue Characterization, Susceptibility Weighted Imaging, T2*, Myocardial Wall Thickness |
---|
Source: | Magnetic Resonance in Medicine |
---|
ISSN: | 0740-3194 |
---|
Publisher: | Wiley-Blackwell |
---|
Volume: | 77 |
---|
Number: | 6 |
---|
Page Range: | 2381-2389 |
---|
Date: | June 2017 |
---|
Official Publication: | https://doi.org/10.1002/mrm.26312 |
---|
PubMed: | View item in PubMed |
---|
Repository Staff Only: item control page
Downloads per month over past year
|