Adenosine modulates transmission at the hippocampal mossy fibre synapse via direct inhibition of presynaptic calcium channels

Item Type:	Article
Title:	Adenosine modulates transmission at the hippocampal mossy fibre synapse via direct inhibition of presynaptic calcium channels
Creators Name:	Gundlfinger, A. and Bischofberger, J. and Johenning, F.W. and Torvinen, M. and Schmitz, D. and Breustedt, J.
Abstract:	The modulation of synaptic transmission by presynaptic ionotropic and metabotropic receptors is an important means to control and dynamically adjust synaptic strength. Even though synaptic transmission and plasticity at the hippocampal mossy fibre synapse are tightly controlled by presynaptic receptors, little is known about the downstream signalling mechanisms and targets of the different receptor systems. In the present study, we identified the cellular signalling cascade by which adenosine modulates mossy fibre synaptic transmission. By means of electrophysiological and optical recording techniques, we found that adenosine activates presynaptic A1 receptors and reduces Ca2+ influx into mossy fibre terminals. Ca2+ currents are directly modulated via a membrane-delimited pathway and the reduction of presynaptic Ca2+ influx can explain the inhibition of synaptic transmission. Specifically, we found that adenosine modulates both P/Q- and N-type presynaptic voltage-dependent Ca2+ channels and thereby controls transmitter release at the mossy fibre synapse.
Keywords:	Adenosine, Adenosine A1Receptor, Aniline Compounds, Calcium Signaling, Confocal Microscopy, Electric Stimulation, Fluoresceins, Fluorescent Dyes, Hippocampal Mossy Fibers, Ion Channel Gating, Neural Inhibition, Neurological Models, N-Type Calcium Channels, Patch-Clamp Techniques, Presynaptic Terminals, Synaptic Transmission, Time Factors, Animals, Mice
Source:	Journal of Physiology
ISSN:	0022-3751
Publisher:	Blackwell Publishing
Volume:	582
Number:	Pt 1
Page Range:	263-277
Date:	1 July 2007
Official Publication:	https://doi.org/10.1113/jphysiol.2007.132613
PubMed:	View item in PubMed

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