Healthy and infarcted brain tissues studied at short diffusion times: the origins of apparent restriction and the reduction in apparent diffusion coefficient

Item Type:	Article
Title:	Healthy and infarcted brain tissues studied at short diffusion times: the origins of apparent restriction and the reduction in apparent diffusion coefficient
Creators Name:	Norris, D.G. and Niendorf, T. and Leibfritz, D.
Abstract:	The significance of NMR water diffusion measurements performed at short diffusion times (<10 ms) for brain tissue is examined. An apparent restriction to diffusion for both healthy and cytotoxically edematous tissue is shown: cytotoxic edema lengthens the diffusion time at which this phenomenon is visible. The dramatic reduction in apparent diffusion coefficient (ADC) observed in the core of cytotoxic edema is explained in terms of the enclosure of extracellular water in non-contiguous pockets in conjunction with the shift of water from the extra-to the intracellular space. The model presented provides an explanation for the ADC reduction without recourse to changes in the cell membrane permeability to water, or unrealistic values for the extra- and intracellular diffusion coefficients.
Keywords:	Cerebral-Ischemia, Water Diffusion, Stroke, Edema, Animals, Cats
Source:	NMR in Biomedicine
ISSN:	0952-3480
Publisher:	Wiley
Volume:	7
Number:	7
Page Range:	304-310
Date:	November 1994
Official Publication:	https://doi.org/10.1002/nbm.1940070703
PubMed:	View item in PubMed

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