Detection of apparent restricted diffusion in healthy rat brain at short diffusion times

Item Type:	Article
Title:	Detection of apparent restricted diffusion in healthy rat brain at short diffusion times
Creators Name:	Niendorf, T. and Norris, D.G. and Leibfritz, D.
Abstract:	The application of bipolar diffusion sensitizing gradient pulses to significantly reduce the diffusion time is described. This approach is combined with the rapid U-FLARE imaging sequence. Three diffusion-sensitized types of experiments are compared and their suitability for detecting restricted diffusion is discussed. Experiments using a modification of the diffusion weighting by varying the diffusion time between 1.6 and 6.0 ms obtained nonmonoexponential signal attenuation curves from both healthy brains and postmortem. This behavior is indicative of restricted diffusion, but as it is detectable only at short diffusion times, in contrast to a restriction due to impermeable barriers, we have termed this "apparent restriction."
Keywords:	Magnetic Resonance Imaging, Water Diffusion, Apparent Restriction, Rat Brain, Animals, Rats
Source:	Magnetic Resonance in Medicine
ISSN:	0740-3194
Publisher:	Wiley
Volume:	32
Number:	5
Page Range:	672-677
Date:	November 1994
Official Publication:	https://doi.org/10.1002/mrm.1910320520
PubMed:	View item in PubMed

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