Cognitive MR spectroscopy of anterior cingulate cortex in ADHD: elevated choline signal correlates with slowed hit reaction times

Item Type:	Article
Title:	Cognitive MR spectroscopy of anterior cingulate cortex in ADHD: elevated choline signal correlates with slowed hit reaction times
Creators Name:	Colla, M. and Ende, G. and Alm, B. and Deuschle, M. and Heuser, I. and Kronenberg, G.
Abstract:	The anterior cingulate cortex (ACC) plays a major role in modulating executive control of attention. Here, 15 medication-nai ve patients with attention deficit/hyperactivity disorder (ADHD) and 10 carefully matched healthy controls were studied with 2D (1)H-magnetic resonance spectroscopic imaging (MRSI) of the ACC [Brodmann areas 24b'-c' and 32']. Attentional skills were assessed using the identical pairs version of the continuous performance task (CPT-IP). Analysis of regional brain spectra revealed a significantly increased signal of choline-containing compounds (Ch) in the ACC of ADHD patients (p<0.05). Across and within groups, the Ch signal showed high correlations with slowed hit reaction times on the CPT-IP. No group differences in N-acetyl-aspartate (NAA) and creatine (tCr) were detectable. The combination of performance deficits and elevated Ch levels in the ACC supports the hypothesis that subtle structural abnormalities underlie the functional alterations in ACC activation previously observed in ADHD patients.
Keywords:	Attention Deficit Disorder with Hyperactivity, Cerebral Cortex, Choline, Diagnostic and Statistical Manual of Mental Disorders, Gyrus Cinguli, Magnetic Resonance Spectroscopy, Reaction Time, Severity of Illness Index, Computer-Assisted Signal Processing
Source:	Journal of Psychiatric Research
ISSN:	0022-3956
Publisher:	Elsevier
Volume:	42
Number:	7
Page Range:	587-595
Date:	June 2008
Official Publication:	https://doi.org/10.1016/j.jpsychires.2007.06.006
PubMed:	View item in PubMed

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