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| Item Type: | Article |
|---|---|
| Title: | Hepatocarcinogenesis in mice with a conditional knockout of the hepatocyte growth factor receptor c-Met |
| Creators Name: | Marx-Stoelting, P., Borowiak, M., Knorpp, T., Birchmeier, C., Buchmann, A. and Schwarz, M. |
| Abstract: | The receptor for the hepatocyte growth factor/scatter factor (HGF/SF), c-Met, plays a role in tumour promotion, progression and metastasis. In this study, we analysed chemically induced hepatocarcinogenesis in mice lacking a functional HGF receptor in their liver. Control and c-Met deficient mice were injected with a single dose of N-nitrosodiethylamine (DEN, 90 mug/g b.wt.) at 6 weeks of age and mice were subsequently kept on a phenobarbital (PB) containing diet (0.05%) for 35 weeks or on control diet. At the end of the experiment, the carcinogenic response in liver of the animals was monitored. Conditional c-met knockout (KO) mice showed a higher prevalence of macroscopically visible liver tumours and of glutamine synthetase positive and glucose-6-phosphatase deficient lesions in liver. Tumour promotion by PB led to significant increases in the number of preneoplastic and neoplastic lesions in liver of both wild-type and c-met knockout mice, with only minor differences in response. Our results indicate that a defect in c-Met-mediated signaling increases chemically induced tumour initiation in liver but does not significantly affect PB-mediated tumour promotion. |
| Keywords: | Tumour Initiation, Tumour Promotion, Liver, Phenobarbital, c-Met, beta-catenin, Animals, Mice |
| Source: | International Journal of Cancer |
| ISSN: | 0020-7136 |
| Publisher: | Wiley |
| Volume: | 124 |
| Number: | 8 |
| Page Range: | 1767-1772 |
| Date: | 15 April 2009 |
| Official Publication: | https://doi.org/10.1002/ijc.24167 |
| PubMed: | View item in PubMed |
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