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Epstein-Barr virus-associated B-cell lymphoma secondary to FCD-C therapy in patients with peripheral T-cell lymphoma

Item Type:Article
Title:Epstein-Barr virus-associated B-cell lymphoma secondary to FCD-C therapy in patients with peripheral T-cell lymphoma
Creators Name:Weisel, K.C. and Weidmann, E. and Anagnostopoulos, I. and Kanz, L. and Pezzutto, A. and Subklewe, M.
Abstract:Epstein-Barr virus (EBV)-associated B-cell lymphoproliferative disorders occur at an increasing frequency in various hereditary and acquired states of immune dysfunction. In a few cases of T-cell lymphoma, especially in angioimmunoblastic T-cell lymphoma (AILT), EBV-associated B-cell lymphoproliferative disorders have been reported. Here, we present two cases of EBV-associated B-cell lymphoma after treatment of T-cell lymphoma (AILT and peripheral T-cell lymphoma, unspecified, PTCL-NOS) with a regimen containing alemtuzumab and fludarabine. Conventional and immunohistological tissue staining showed the typical features of highly proliferating diffuse large B-cell lymphoma in both cases. The monoclonal B-cell population displayed EBV latency type III. At the time of diagnosis the cellular immune status of both patients was severely compromised with an absolute CD4 T-cell count below <120 mul(-1). Our observation supports the notion that combination of cytotoxic drugs and immunosuppressive antibodies in patients with T-cell lymphoma may severely aggravate the already present immunodeficiency. We suggest to monitor the cellular immune status in combination with the EBV load in high risk patients for early detection-and possibly intervention-of EBV-associated lymphoma.
Keywords:Epstein–Barr Virus, Secondary B-Cell Lymphoma, Peripheral T-Cell Lymphoma, AILT, Alemtuzumab, Fludarabine
Source:International Journal of Hematology
ISSN:0925-5710
Publisher:Springer (Japan)
Volume:88
Number:4
Page Range:434-440
Date:November 2008
Official Publication:https://doi.org/10.1007/s12185-008-0176-2
PubMed:View item in PubMed

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