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Neuregulin-1, a key axonal signal that drives Schwann cell growth and differentiation

Item Type:Article
Title:Neuregulin-1, a key axonal signal that drives Schwann cell growth and differentiation
Creators Name:Birchmeier, C. and Nave, K.A.
Abstract:Interactions between neuronal and glial cells are crucial for establishing a functional nervous system. Many aspects of Schwann cell development and physiology are regulated by neuronal signals; possibly the most spectacular is the elaboration of the myelin sheath. An extensive line of research has revealed that one neuronal factor, termed "neuregulin", promotes Schwann cell growth and survival, migration along the extending axon, and myelination. The versatility of glial responses elicited by this factor is thus clearly astounding.
Keywords:Neuregulin, Schwann Cell, Myelination, Animals
Source:Glia
ISSN:0894-1491
Publisher:Wiley (U.S.A.)
Volume:56
Number:14
Page Range:1491-1497
Date:1 November 2008
Official Publication:https://doi.org/10.1002/glia.20753
PubMed:View item in PubMed

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