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| Item Type: | Article |
|---|---|
| Title: | Succesful long-term monotherapy with rituximab in a chemotherapy-refractory patient with chronic B-CLL: a case report |
| Creators Name: | Sturm, I. and Oertel, J. and Oertel, S. and Westermann, J. and Pezzutto, A. |
| Abstract: | INTRODUCTION: Treatment of chronic lymphocytic leukemia of the B-cell-lineage is strongly based upon clinical staging because of the heterogeneous clinical course of this disease. CASE PRESENTATION: We describe a 62-year-old patient with newly diagnosed chronic lymphocytic leukemia of the B-cell-lineage who did not respond to several chemotherapy regimens including chlorambucil, fludarabine and cyclophosphamide, developing a marked neutropenia and thrombocytopenia with life-threatening infections. Further chemotherapy appeared not feasible because of bone marrow toxicity. The patient was treated with 600mg/m2 rituximab weekly followed by eight courses of biweekly therapy and then by long-term maintenance therapy, achieving almost complete remission of the symptoms and disease control. CONCLUSIONS: After resistance to standard chemotherapy with chlorambucil and fludarabine, a patient with chronic lymphocytic leukemia of the B-cell-lineage was successfully treated with rituximab. |
| Source: | Journal of Medical Case Reports |
| ISSN: | 1752-1947 |
| Publisher: | BioMed Central |
| Volume: | 2 |
| Number: | 1 |
| Page Range: | 275 |
| Date: | 14 August 2008 |
| Official Publication: | https://doi.org/10.1186/1752-1947-2-275 |
| PubMed: | View item in PubMed |
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