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Succesful long-term monotherapy with rituximab in a chemotherapy-refractory patient with chronic B-CLL: a case report

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Item Type:Article
Title:Succesful long-term monotherapy with rituximab in a chemotherapy-refractory patient with chronic B-CLL: a case report
Creators Name:Sturm, I. and Oertel, J. and Oertel, S. and Westermann, J. and Pezzutto, A.
Abstract:INTRODUCTION: Treatment of chronic lymphocytic leukemia of the B-cell-lineage is strongly based upon clinical staging because of the heterogeneous clinical course of this disease. CASE PRESENTATION: We describe a 62-year-old patient with newly diagnosed chronic lymphocytic leukemia of the B-cell-lineage who did not respond to several chemotherapy regimens including chlorambucil, fludarabine and cyclophosphamide, developing a marked neutropenia and thrombocytopenia with life-threatening infections. Further chemotherapy appeared not feasible because of bone marrow toxicity. The patient was treated with 600mg/m2 rituximab weekly followed by eight courses of biweekly therapy and then by long-term maintenance therapy, achieving almost complete remission of the symptoms and disease control. CONCLUSIONS: After resistance to standard chemotherapy with chlorambucil and fludarabine, a patient with chronic lymphocytic leukemia of the B-cell-lineage was successfully treated with rituximab.
Source:Journal of Medical Case Reports
ISSN:1752-1947
Publisher:BioMed Central (U.K.)
Volume:2
Number:1
Page Range:275
Date:14 August 2008
Official Publication:https://doi.org/10.1186/1752-1947-2-275
PubMed:View item in PubMed

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