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IkappaBalpha is required for marginal zone B cell lineage development

Item Type:Article
Title:IkappaBalpha is required for marginal zone B cell lineage development
Creators Name:Ellinghaus, U. and Rupec, R.A. and Pabst, O. and Ignatius, R. and Foerster, R. and Doerken, B. and Jundt, F.
Abstract:Inactivation of members of the nuclear factor-kappaB (NF-kappaB) family results in the decrease or defect of marginal zone B (MZB) cells. It is not known which inhibitors of the NF-kappaB family (IkappaB) are required for MZB cell development. Here, we show that mice with B cell-specific inactivation of the main NF-kappaB inhibitor IkappaBalpha have a marked decrease of MZB cells and their presumed precursors. They exhibited increased mortality rates after blood-borne bacterial infection, indicating the importance of MZB cells for bacterial clearance. In contrast, response to T cell-dependent and -independent antigens resulted only in minor changes in immunoglobulin production. Our data demonstrate the importance of the intact NF-kappaB/IkappaBalpha pathway for proper MZB cell development.
Keywords:Conditional Knockout, Marginal Zone B Cells, NF-B Pathway, Animals, Mice
Source:European Journal of Immunology
ISSN:0014-2980
Publisher:Wiley (U.S.A.)
Volume:38
Number:8
Page Range:2096-2105
Date:August 2008
Official Publication:https://doi.org/10.1002/eji.200838254
PubMed:View item in PubMed

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