E-I balance and human diseases - from molecules to networking

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Item Type:	Article
Title:	E-I balance and human diseases - from molecules to networking
Creators Name:	Eichler, S.A. and Meier, J.C.
Abstract:	Information transfer in the brain requires a homeostatic control of neuronal excitability. Therefore, a functional balance between excitatory and inhibitory systems is established during development. This review contains recent information about the molecular mechanisms orchestrating the establishment and maintenance of this excitation-inhibition (E-I) balance, and it reviews examples of deregulation of inhibitory and excitatory systems at a molecular, network and disease level of investigation.
Keywords:	Development, Excitation-inhibition balance, Homeostasis, Hyperexcitability, Autism, Nervous system disorders, Excitation, Inhibition, E-I balance, Mental retardation, Schizophrenia, Alzheimer's disease, Rett Syndrome
Source:	Frontiers in Molecular Neuroscience
ISSN:	1662-5099
Publisher:	Frontiers Media SA
Volume:	1
Number:	2
Date:	28 March 2008
Official Publication:	https://doi.org/10.3389/neuro.02.002.2008
PubMed:	View item in PubMed

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