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| Item Type: | Article |
|---|---|
| Title: | NetworKIN: a resource for exploring cellular phosphorylation networks |
| Creators Name: | Linding, R. and Jensen, L.J. and Pasculescu, A. and Olhovsky, M. and Colwill, K. and Bork, P. and Yaffe, M.B. and Pawson, T. |
| Abstract: | Protein kinases control cellular responses by phosphorylating specific substrates. Recent proteome-wide mapping of protein phosphorylation sites by mass spectrometry has discovered thousands of in vivo sites. Systematically assigning all 518 human kinases to all these sites is a challenging problem. The NetworKIN database (http://networkin.info) integrates consensus substrate motifs with context modelling for improved prediction of cellular kinase-substrate relations. Based on the latest human phosphoproteome from the Phospho.ELM and PhosphoSite databases, the resource offers insight into phosphorylation-modulated interaction networks. Here, we describe how NetworKIN can be used for both global and targeted molecular studies. Via the web interface users can query the database of precomputed kinase-substrate relations or obtain predictions on novel phosphoproteins. The database currently contains a predicted phosphorylation network with 20 224 site-specific interactions involving 3978 phosphoproteins and 73 human kinases from 20 families. |
| Keywords: | Amino Acid Sequence, Consensus Sequence, Internet, Phosphoproteins, Phosphorylation, Protein Databases, Protein Kinases, Proteomics, User-Computer Interface |
| Source: | Nucleic Acids Research |
| ISSN: | 0305-1048 |
| Publisher: | Oxford University Press |
| Volume: | 36 |
| Number: | Database issue |
| Page Range: | D695-D699 |
| Date: | January 2008 |
| Official Publication: | https://doi.org/10.1093/nar/gkm902 |
| PubMed: | View item in PubMed |
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