Chromosomal rearrangements involving the BCL3 locus are recurrent in classical Hodgkin and peripheral T-cell lymphoma

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Item Type:	Letter
Title:	Chromosomal rearrangements involving the BCL3 locus are recurrent in classical Hodgkin and peripheral T-cell lymphoma
Creators Name:	Martin-Subero, J.I., Wlodarska, I., Bastard, C., Picquenot, J.M., Hoeppner, J., Giefing, M., Klapper, W., Siebert, R., Mathas, S., Joos, S., Stein, H. and Doerken, B.
Abstract:	In a recent issue of Blood, Mathas et al suggested elevated BCL3 expression to be functionally important in classical Hodgkin lymphoma (cHL) and peripheral T-cell lymphoma (PTCL). The authors reported strong BCL3 protein expression in the vast majority of cHLs and a subset of PTCLs.1 These results corroborated similar immunohistochemical findings by Canoz et al. Mathas et al reported chromosomal gains of the BCL3 locus in chromosome band 19q13 as a potential cause of BCL3 upregulation in 3 of 6 cHL cell lines and 8 of 37 PTCLs. Here, we provide evidence that not only chromosomal gains but also translocations affecting the BCL3 locus are recurrent in cHL and PTCL. [beginning of text]
Keywords:	Chromosome Aberrations, Fluorescence In Situ Hybridization, Hodgkin Disease, Peripheral T-Cell Lymphoma, Proto-Oncogene Proteins, Recurrence, Transcription Factors
Source:	Blood
ISSN:	0006-4971
Publisher:	American Society of Hematology
Volume:	108
Page Range:	401-403
Date:	1 July 2006
Official Publication:	https://doi.org/10.1182/blood-2005-09-3843
PubMed:	View item in PubMed

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