Differential requirements for the chemokine receptor CCR7 in T cell activation during Listeria monocytogenes infection

Kursar, M.; Höpken, U.E.; Koch, M.; Koehler, A.; Lipp, M.; Kaufmann, S.H.; Mittrücker, H.W.

Differential requirements for the chemokine receptor CCR7 in T cell activation during Listeria monocytogenes infection

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Item Type:	Article
Title:	Differential requirements for the chemokine receptor CCR7 in T cell activation during Listeria monocytogenes infection
Creators Name:	Kursar, M., Höpken, U.E., Koch, M., Koehler, A., Lipp, M., Kaufmann, S.H. and Mittrücker, H.W.
Abstract:	Effective priming of T cell responses depends on cognate interactions between naive T cells and professional antigen-presenting cells (APCs). This contact is the result of highly coordinated migration processes, in which the chemokine receptor CCR7 and its ligands, CCL19 and CCL21, play a central role. We used the murine Listeria monocytogenes infection model to characterize the role of the CCR7/CCR7 ligand system in the generation of T cell responses during bacterial infection. We demonstrate that efficient priming of naive major histocompatibility complex (MHC) class Ia-restricted CD8+ T cells requires CCR7. In contrast, MHC class Ib-restricted CD8+ T cells and MHC class II-restricted CD4+ T cells seem to be less dependent on CCR7; memory T cell responses are independent of CCR7. Infection experiments with bone marrow chimeras or mice reconstituted with purified T cell populations indicate that CCR7 has to be expressed on CD8+ T cells and professional APCs to promote efficient MHC class Ia-restricted T cell priming. Thus, different T cell subtypes and maturation stages have discrete requirements for CCR7.
Keywords:	Antigen-Presenting Cells, Bone Marrow Cells, CD8-Positive T-Lymphocytes, Chemokine CCL19, Chemokine CCL21, DNA Primers, Flow Cytometry, Immunologic Memory, Listeria Infections, Listeria monocytogenes, Lymphocyte Activation, Major Histocompatibility Complex, CCR7 Receptors, Chemokine Receptors, T-Lymphocyte Subsets, Animals, Mice
Source:	Journal of Experimental Medicine
ISSN:	0022-1007
Publisher:	Rockefeller University Press
Volume:	201
Number:	9
Page Range:	1447-1457
Date:	2 May 2005
Additional Information:	Copyright (c) 2005 by The Rockefeller University Press
Official Publication:	https://doi.org/10.1084/jem.20041204
PubMed:	View item in PubMed

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