![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Tools
Tools
| Item Type: | Article |
|---|---|
| Title: | CD38 low IgG-secreting cells are precursors of various CD38 high-expressing plasma cell populations |
| Creators Name: | Arce, S., Luger, E., Muehlinghaus, G., Cassese, G., Hauser, A., Horst, A., Lehnert, K., Odendahl, M., Hoenemann, D., Heller, K.D., Kleinschmidt, H., Berek, C., Doerner, T., Krenn, V., Hiepe, F., Bargou, R., Radbruch, A. and Manz, R.A. |
| Abstract: | Despite the important role immunoglobulin G (IgG)-secreting plasma cells play in memory immune responses, the differentiation and homeostasis of these cells are not completely understood. Here, we studied the differentiation of human IgG-secreting cells ex vivo and in vitro, identifying these cells by the cellular affinity matrix technology. Several subpopulations of IgG-secreting cells were identified among the cells isolated from tonsils and bone marrow, particularly differing in the expression levels of CD9, CD19, and CD38. CD38 low IgG-secreting cells were present exclusively in the tonsils. A major fraction of these cells appeared to be early plasma cell precursors, as upon activation of B cells in vitro, IgG secretion preceded up-regulation of CD38, and on tonsillar sections, IgG-containing, CD38 low cells with a plasmacytoid phenotype were found in follicles, where plasma cell differentiation starts. A unitary phenotype of migratory peripheral blood IgG-secreting cells suggests that all bone marrow plasma cell populations share a common precursor cell. These data are compatible with a multistep model for plasma cell differentiation and imply that a common CD38 low IgG-secreting precursor gives rise to a diverse plasma cell compartment. |
| Keywords: | Antibodies, B lymphocytes, Cellular differentiation, Memory |
| Source: | Journal of Leukocyte Biology |
| ISSN: | 0741-5400 |
| Volume: | 75 |
| Page Range: | 1022-1028 |
| Date: | 1 January 2004 |
| Official Publication: | https://doi.org/10.1189/jlb.0603279 |
| PubMed: | View item in PubMed |
Repository Staff Only: item control page
