T cell recognition of bcr/abl in healthy donors and in patients with chronic myeloid leukaemia

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Item Type:	Article
Title:	T cell recognition of bcr/abl in healthy donors and in patients with chronic myeloid leukaemia
Creators Name:	Westermann, J., Schlimper, C., Richter, G., Mohm, J., Doerken, B. and Pezzutto, A.
Abstract:	In chronic myeloid leukaemia (CML), peptides from the fusion region of bcr3/abl2 are likely to play a role in anti-leukaemic T cell immunity. We investigated whether T cells that recognize bcr/abl fusion peptides could be detected in healthy donors and CML patients. T cell responses against bcr3/abl2 fusion peptides were analysed by {gamma}-interferon enzyme-linked immunospot assays after prestimulation of peripheral blood mononuclear cells in the presence of anti-CD3-antibodies and interleukin-2. Our results suggest that the T cell repertoire contains bcr3/abl2-reactive T cells in CML patients who are in cytogenetic remission, but also in some healthy individuals.
Keywords:	Chronic Myeloid Leukaemia, bcr/abl, T Cell Response
Source:	British Journal of Haematology
ISSN:	0007-1048
Publisher:	Blackwell Publishing
Volume:	125
Number:	2
Page Range:	213-216
Date:	1 April 2004
Official Publication:	https://doi.org/10.1111/j.1365-2141.2004.04873.x
PubMed:	View item in PubMed

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