Helmholtz Gemeinschaft

Search
Browse
Statistics
Feeds

Impact of selection, mutation rate and genetic drift on human genetic variation

Item Type:Article
Title:Impact of selection, mutation rate and genetic drift on human genetic variation
Creators Name:Sunyaev, S. and Kondrashov, F.A. and Bork, P. and Ramensky, V.
Abstract:The accumulation of genome-wide information on single nucleotide polymorphisms in humans provides an unprecedented opportunity to detect the evolutionary forces responsible for heterogeneity of the level of genetic variability across loci. Previous studies have shown that history of recombination events has produced long haplotype blocks in the human genome, which contribute to this heterogeneity. Other factors, however, such as natural selection or the heterogeneity of mutation rates across loci, may also lead to heterogeneity of genetic variability. We compared synonymous and non-synonymous variability within human genes with their divergence from murine orthologs. We separately analyzed the non-synonymous variants predicted to damage protein structure or function and the variants predicted to be functionally benign. The predictions were based on comparative sequence analysis and, in some cases, on the analysis of protein structure. A strong correlation between non-synonymous, benign variability and non-synonymous human-mouse divergence suggests that selection played an important role in shaping the pattern of variability in coding regions of human genes. However, the lack of correlation between deleterious variability and evolutionary divergence shows that a substantial proportion of the observed non-synonymous single-nucleotide polymorphisms reduces fitness and never reaches fixation. Evolutionary and medical implications of the impact of selection on human polymorphisms are discussed.
Keywords:Genetic Drift, Mutation, Selection, Single Nucleotide Polymorphism, Statistics, Variation, Animals, Mice
Source:Human Molecular Genetics
ISSN:0964-6906
Publisher:Oxford University Press (U.K.)
Volume:12
Number:24
Page Range:3325-3330
Date:1 January 2003
Official Publication:https://doi.org/10.1093/hmg/ddg359
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library