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| Item Type: | Article |
|---|---|
| Title: | Role of β-catenin in synaptic vesicle localization and presynaptic assembly |
| Creators Name: | Bamji, S.X., Shimazu, K., Kimes, N., Huelsken, J., Birchmeier, W., Lu, B. and Reichardt, L.F. |
| Abstract: | Cadherins and catenins are thought to promote adhesion between pre and postsynaptic elements in the brain. Here we show a role for {beta}-catenin in localizing the reserved pool of vesicles at presynaptic sites. Deletion of {beta}-catenin in hippocampal pyramidal neurons in vivo resulted in a reduction in the number of reserved pool vesicles per synapse and an impaired response to prolonged repetitive stimulation. This corresponded to a dispersion of vesicles along the axon in cultured neurons. Interestingly, these effects are not due to {beta}-catenin's involvement in cadherin-mediated adhesion or wnt signaling. Instead, {beta}-catenin modulates vesicle localization via its PDZ binding domain to recruit PDZ proteins such as Veli to cadherin at synapses. This study defines a specific role for cadherins and catenins in synapse organization beyond their roles in mediating cell adhesion. |
| Keywords: | Beta Catenin, Cadherins, Carrier Proteins, Cultured Cells, Cytoskeletal Proteins, Electric Stimulation, Electron Microscopy, Fetus, Presynaptic Terminals, Pyramidal Cells, Synaptic Membranes, Synaptic Transmission, Synaptic Vesicles, Tertiary Protein Structure, Trans-Activators, Transgenic Mice, Animals, Mice, Rats |
| Source: | Neuron |
| ISSN: | 0896-6273 |
| Publisher: | Cell Press |
| Volume: | 40 |
| Number: | 4 |
| Page Range: | 719-731 |
| Date: | November 2003 |
| Official Publication: | https://doi.org/10.1016/S0896-6273(03)00718-9 |
| PubMed: | View item in PubMed |
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