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A critical requirement of interferon gamma-mediated angiostasis for tumor rejection by CD8T cells

Item Type:Article
Title:A critical requirement of interferon gamma-mediated angiostasis for tumor rejection by CD8T cells
Creators Name:Qin, Z.H. and Schwartzkopff, J. and Pradera, F. and Kammertoens, T. and Seliger, B. and Pircher, H. and Blankenstein, T.
Abstract:It is thought that tumor rejection by CD8+ T-cell effectors is primarily mediated by direct killing. We show that rejection of different tumors (fibrosarcoma, ras-transformed fibroblasts, colon carcinoma, and plasmacytoma) by CD8+ T cells is always preceded by inhibition of tumor-induced angiogenesis. Angiostasis and tumor rejection were observed in perforin but not in IFN-γ-deficient mice. Furthermore, adoptive transfer of tumor-specific CD8+ T cells from IFN-γ-competent mice inhibited angiogenesis of lung metastases in comparison to those from IFN-γ gene-deficient mice. Taken together with our previous findings, we conclude that IFN-γ-dependent antiangiogenesis is a general mechanism involved in tumor rejection by CD4+ and CD8+ T-cell effectors.
Keywords:Ascitic Fluid, Chromium Radioisotopes, Experimental Neoplasms, Fibrosarcoma, Histocompatibility Antigens, Immunologic Cytotoxicity, Inbred C57BL Mice, Kinetics, Methylcholanthrene, Neoplasm Antigens, P.H.S. U.S. Govt Support, T-Lymphocytes, Animals, Mice
Source:Cancer Research
ISSN:0008-5472
Publisher:American Association for Cancer Research (U.S.A.)
Volume:63
Number:14
Page Range:4095-4100
Date:1 January 2003
Official Publication:http://cancerres.aacrjournals.org/cgi/content/abstract/63/14/4095
PubMed:View item in PubMed

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