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Cutting edge: CD8+ effector T cells reject tumors by direct antigen recognition but indirect action on host cells

Item Type:Article
Title:Cutting edge: CD8+ effector T cells reject tumors by direct antigen recognition but indirect action on host cells
Creators Name:Schueler, T. and Blankenstein, T.
Abstract:CD8+ effector T cells recognize malignant cells by monitoring their surface for the presence of tumor-derived peptides bound to MHC class I molecules. In addition, tumor-derived Ags can be cross-presented to CD8+ effector T cells by APCs. IFN-γ production by CD8+ T cells is often critical for tumor rejection. However, it remained unclear whether 1) CD8+ T cells secrete IFN-γ in response to Ag recognition on tumor cells or APCs and 2) whether IFN-γ mediates its antitumor effect by acting on host or tumor cells. We show in this study that CD8+ effector T cells can reject tumors in bone marrow-chimeric mice incapable of cross-presenting Ag by bone marrow-derived APCs and that tumor rejection required host cells to express IFN-γR. Together, CD8+ effector T cells recognize Ag directly on tumor cells, and this recognition is sufficient to reject tumors by IFN-γ acting on host cells.
Keywords:Antigen Presentation, Antigen-Presenting Cells, Bone Marrow Cells, CD8-Positive T-Lymphocytes, Cultured Cells, Cultured Tumor Cells, Experimental Melanoma, Graft Rejection, Inbred C57BL Mice, Interferon Type II, Interferon Receptors, Knockout Mice, Neoplasm Antigens, Neoplasm Transplantation, Ovalbumin, Transgenic Mice, Animals, Mice
Source:Journal of Immunology
ISSN:0022-1767
Publisher:American Association of Immunologists (U.S.A.)
Volume:170
Number:9
Page Range:4427-4431
Date:1 May 2003
Official Publication:http://www.jimmunol.org/cgi/content/abstract/170/9/4427
PubMed:View item in PubMed

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