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Recent improvements to the SMART domain-based sequence annotation resource

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Item Type:Article
Title:Recent improvements to the SMART domain-based sequence annotation resource
Creators Name:Letunic, I. and Goodstadt, L. and Dickens, N.J. and Doerks, T. and Schultz, J. and Mott, R. and Ciccarelli, F. and Copley, R.R. and Ponting, C.P. and Bork, P.
Abstract:SMART (Simple Modular Architecture Research Tool, http://smart.embl-heidelberg.de) is a web-based resource used for the annotation of protein domains and the analysis of domain architectures, with particular emphasis on mobile eukaryotic domains. Extensive annotation for each domain family is available, providing information relating to function, subcellular localization, phyletic distribution and tertiary structure. The January 2002 release has added more than 200 hand-curated domain models. This brings the total to over 600 domain families that are widely represented among nuclear, signalling and extracellular proteins. Annotation now includes links to the Online Mendelian Inheritance in Man (OMIM) database in cases where a human disease is associated with one or more mutations in a particular domain. We have implemented new analysis methods and updated others. New advanced queries provide direct access to the SMART relational database using SQL. This database now contains information on intrinsic sequence features such as transmembrane regions, coiled-coils, signal peptides and internal repeats. SMART output can now be easily included in users' documents. A SMART mirror has been created at http://smart.ox.ac.uk.
Keywords:Protein Databases, Human Genome, Information Storage and Retrieval, Internet, Protein Sorting Signals, Tertiary Protein Structure, Proteins, Quality Control, Amino Acid Repetitive Sequences, Sequence Alignment, Amino Acid Sequence Homology, Animals
Source:Nucleic Acids Research
Publisher:Oxford University Press
Page Range:242-244
Date:1 January 2002
Official Publication:http://nar.oxfordjournals.org/cgi/content/abstract/30/1/242
PubMed:View item in PubMed

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